Redox-Redux and NADPH Oxidase (NOX): Even More Complicated than We Thought it Might Be

Treatment of rectal chlamydia infection may be more complicated than we originally thought.

Rectal chlamydia diagnoses have been increasing among MSM and may also rise among women as anal sex rates increase among heterosexuals. However, there is growing concern about treatment for rectal chlamydia with treatment failures of up to 22% being reported. This article addresses factors that may be contributing to treatment failure for rectal chlamydia, including the pharmacokinetic properti...

More ties than we thought

We extend the existing enumeration of neck tie knots to include tie knots with a textured front, tied with the narrow end of a tie. These tie knots have gained popularity in recent years, based on reconstructions of a costume detail from The Matrix Reloaded, and are explicitly ruled out in the enumeration by Fink and Mao (2000). We show that the relaxed tie knot description language that compre...

Immunodeficiency - “ Much More Common Than We Thought ”

10 years with the development of new genetic techniques more than 100 mutations in various genes were found to be associated with primary immunodeficiencies entities. It should be noted that in some diseases several hundreds of patients were found, while in others only few children were discovered, thus applying that we are dealing with rare situations. Using the same genetic techniques a new c...

Screening trials are even more difficult than we thought they were.

In this issue of the Journal, Black et al. (1) present an important analysis of methodologic pitfalls associated with randomized studies of screening interventions. The authors compare disease-specific and all-cause mortality from the 12 published randomized trials of cancer screening for which these end points were available. In seven of the 12 studies, major inconsistencies were detected in t...

The dairy fat paradox: Whole dairy products may be healthier than we thought